منابع مشابه
Targeted uptake-1 carrier to rescue the failing heart.
Heart failure is characterized by sympathetic nervous system activation with consequent increase in cardiac and systemic norepinephrine (NE) release. Sympathetic hyperactivity preferentially targets the heart during early stages of failure and subsequently involves other organs. A landmark study published in 1984 by Cohn et al showed that plasma NE concentration in venous blood sampled at rest ...
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The tumor suppressor p53 is mutationally inactivated in approximately 50% of human cancers. Approximately one-third of the mutations lower the melting temperature of the protein, leading to its rapid denaturation. Small molecules that bind to those mutants and stabilize them could be effective anticancer drugs. The mutation Y220C, which occurs in approximately 75,000 new cancer cases per annum,...
متن کاملGenetic rescue to the rescue.
Genetic rescue can increase the fitness of small, imperiled populations via immigration. A suite of studies from the past decade highlights the value of genetic rescue in increasing population fitness. Nonetheless, genetic rescue has not been widely applied to conserve many of the threatened populations that it could benefit. In this review, we highlight recent studies of genetic rescue and pla...
متن کاملTargeted early rescue surfactant in ventilated preterm infants using the click test.
OBJECTIVE To determine whether use of the click test, a rapid bedside test of surfactant function, results in earlier and more appropriate surfactant administration in ventilated preterm infants than does usual early rescue treatment. STUDY DESIGN Ventilated preterm infants (n = 126) with inspired oxygen >/=25% and mean airway pressure >/=7 cm H(2)O were randomized in gestational strata (<28 ...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2018
ISSN: 1471-003X,1471-0048
DOI: 10.1038/nrn.2018.29